例如:"lncRNA", "apoptosis", "WRKY"

The Mutation of the Ap3b1 Gene Causes Uterine Hypoplasia in Pearl Mice.

Reprod Sci. 2020 Jan;27(1):182-191. Epub 2020 Jan 01
Renwei Jing 1 , Yu Kong 1 , Gang Han 2 , Jingye Zhang 1 , Kailin Li 1 , Xuan Dong 1 , Jie Yan 1 , Haiqing Zhang 3 , Jia Han 4 , Lijun Feng 5
Renwei Jing 1 , Yu Kong 1 , Gang Han 2 , Jingye Zhang 1 , Kailin Li 1 , Xuan Dong 1 , Jie Yan 1 , Haiqing Zhang 3 , Jia Han 4 , Lijun Feng 5
+ et al

[No authors listed]

Author information
  • 1 Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Institute of Developmental Biology, School of Life Sciences, Shandong University, 250100, Jinan, Shandong, People's Republic of China.
  • 2 School of Medical Laboratory, Tianjin Medical University, 300203, Tianjin, People's Republic of China.
  • 3 Department of Bioengineering, Shandong Polytechnic, 250014, Jinan, Shandong, People's Republic of China.
  • 4 Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Street, Jinan, 250021, China. macromidia@163.com.
  • 5 Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Institute of Developmental Biology, School of Life Sciences, Shandong University, 250100, Jinan, Shandong, People's Republic of China. drfeng@sdu.edu.cn.

摘要


The pearl (pe) mouse mutant has been identified as a model for Hermansky-Pudlak syndrome and bears a mutation in the beta3A subunit of the AP-3 complex, which has a core function in the biogenesis and function of various lysosomal-related organelles. Through large-scale mating, we found that female pearl mice also displayed reduced fertility with a smaller litter size. Abnormal uteri in both 1-month-old and 3-month-old mice were observed as having short and thin uterine horns, indicating abnormal development. Histological studies revealed that the endometrial epithelium and endometrial stoma of the uterus were both thinner than those in the normal controls. We examined some key factors in uterine development, including the Hoxa10, Hoxa11, and Wnt5a genes, and found that they all presented lower mRNA and protein levels. The pearl mouse could serve as a model for uterine hypoplasia, a common problem in female infertility.

KEYWORDS: Pearl mouse, Uterine endometrium, Uterine hypoplasia