Human cationic amino acid transporters are not affected by direct nitros(yl)ation.

Amino Acids. 2020 Mar;52(3):499-503. Epub 2020 Feb 01

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A direct inhibiting effect of NO on the function of CAT-1 and -2A has been postulated to occur via nitrosylation of cysteine residues in the transporters. Neither the NO donor SNAP nor a mixture of SIN-1 and Spermine NONOate, that generates the strong nitrosating agent N₂O₃, reduced CAT-mediated L-arginine transport. Direct nitros(yl)ation does either not occur in CATs or does not affect their transport function. A regulatory effect of NO or nitrosating agents on CAT-mediated transport under physiological conditions seems, therefore, unlikely.

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Human cationic amino acid transporters are not affected by direct nitros(yl)ation.

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