例如:"lncRNA", "apoptosis", "WRKY"

Amine oxidase 3 is a novel pro-inflammatory marker of oxidative stress in peritoneal endometriosis lesions.

Sci Rep. 2020 Jan 30;10(1):1495
Marie-Laëtitia Thézénas 1 , Bianca De Leo 2 , Alexis Laux-Biehlmann 2 , Cemsel Bafligil 3 , Bernd Elger 2 , Thomas Tapmeier 4 , Karl Morten 4 , Nilufer Rahmioglu 5 , Stephanie G Dakin 3 , Philip Charles 1 , Fernando Estrada Martinez 3 , Graham Steers 4 , Oliver M Fischer 2 , Joerg Mueller 2 , Holger Hess-Stumpp 2 , Andreas Steinmeyer 2 , Sanjiv Manek 4 , Krina T Zondervan 5 , Stephen Kennedy 4 , Christian M Becker 4 , Catherine Shang 4 , Thomas M Zollner 2 , Benedikt M Kessler 6 , Udo Oppermann 7
Marie-Laëtitia Thézénas 1 , Bianca De Leo 2 , Alexis Laux-Biehlmann 2 , Cemsel Bafligil 3 , Bernd Elger 2 , Thomas Tapmeier 4 , Karl Morten 4 , Nilufer Rahmioglu 5 , Stephanie G Dakin 3 , Philip Charles 1 , Fernando Estrada Martinez 3 , Graham Steers 4 , Oliver M Fischer 2 , Joerg Mueller 2 , Holger Hess-Stumpp 2 , Andreas Steinmeyer 2 , Sanjiv Manek 4 , Krina T Zondervan 5 , Stephen Kennedy 4 , Christian M Becker 4 , Catherine Shang 4 , Thomas M Zollner 2 , Benedikt M Kessler 6 , Udo Oppermann 7
+ et al

[No authors listed]

Author information
  • 1 Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK.
  • 2 Bayer AG, R&D, Gynaecological Therapies, 13342, Berlin, Germany.
  • 3 Botnar Research Centre, NIHR Biomedical Research Unit Oxford, Nuffield Department of Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.
  • 4 Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology, Oxford, UK.
  • 5 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.
  • 6 Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK. benedikt.kessler@ndm.ox.ac.uk.
  • 7 Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, 79104, Freiburg, Germany. udo.oppermann@ndorms.ox.ac.uk.

摘要


Endometriosis is a common gynaecological disease of women in reproductive age, and is thought to arise from retrograde menstruation and implantation of endometrial tissue, mostly into the peritoneal cavity. The condition is characterized by a chronic, unresolved inflammatory process thereby contributing to pain as cardinal symptom in endometriosis. Elevated reactive oxygen species and oxidative stress have been postulated as factors in endometriosis pathogenesis. We here set out for a systematic study to identify novel mechanisms and pathways relating to oxidative stress in ectopic peritoneal lesions. Using combined proteomic and transcriptomic approaches, we identified novel targets including upregulated pro-oxidative enzymes, such as amine oxidase 3/vascular adhesion protein 1 (AOC3/VAP1) as well as downregulated protective factors, in particular alkenal reductase PTGR1 and methionine sulfoxide reductase. Consistent with an altered landscape, we observed hemoglobin / iron overload, duanyu1670 production and lipid peroxidation in ectopic lesions. 4-hydroxy-2-nonenal induced interleukin IL-8 release from monocytes. Notably, AOC3 inhibitors provoked analgesic effects in inflammatory pain models in vivo, suggesting potential translational applicability.