[No authors listed]
Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of esophageal cancer. miRNA (miR)â542â3p is a tumor suppressor in multiple types of cancer. However, whether and how miRâ542â3p contributes to the progression of esophageal cancer remains unknown, and this is the aim of the present study. In the current study, decreased expression of miRâ542â3p was detected in tumor tissues compared with normal tissues from patients with esophageal cancer, and miRâ542â3p expression was negatively correlated with mRNA expression levels of ovarian tumor domainâcontaining ubiquitin aldehydeâbinding protein 1 (OTUB1) in tumor tissues from patients with esophageal cancer. In KYSE150 human esophageal squamous cell carcinoma cells, overexpression of miRâ542â3p significantly decreased OTUB1 at mRNA and protein levels, whereas downregulation of miRâ542â3p significantly increased OTUB1 expression. Using a dualâluciferase assay, OTUB1 was validated to be a target gene of miRâ542â3p in KYSE150 cells. Functionally, miRâ542â3p significantly inhibited the migration and invasion of KYSE150 cells by repression of OTUB1 expression. These results demonstrated that miRâ542â3p may promote the metastasis of esophageal cancer cells, and indicated that miRâ542â3p may be a treatment target for esophageal cancer.
KEYWORDS: {{ getKeywords(articleDetailText.words) }}
Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
{{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} |
{{ list.authorName }} {{ list.authorName }} |