[No authors listed]
Colorectal cancer is a commonly diagnosed gastrointestinal malignancy worldwide with a high mortality rate. Accumulating evidence has indicated that the expression of a number of microRNAs (miRNAs) is associated with the development of colorectal cancer. However, the precise molecular mechanism of these miRNAs in regulating cancer progression is yet to be determined. In the present study, miRâ3651 was demonstrated to be overexpressed in colorectal cancer tissues compared with normal tissues, and to be associated with the tumorânodeâmetastasis stage. The downregulation of miRâ3651 was found to induce growth arrest and apoptosis in colorectal cancer cells. In addition, western blot analysis demonstrated that the downregulation of miRâ3651 inactivated PI3K/AKT and MAPK/ERK signaling in colorectal cancer cells. Bioinformatics analysis predicted Tâbox transcription factor 1 (TBX1) as a potential target gene of miRâ3651, and a dualâluciferase reporter assay confirmed that TBX1 was directly repressed by miRâ3651. The results of the current study also indicated that TBX1 was associated with the miRâ3651 mediated activation of oncogenic signaling and colorectal cancer cell proliferation. In conclusion, the results of the current study revealed the oncogenic potential of miRâ3651 in colorectal cancer.
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