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CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling.

EMBO Rep. 2020 Mar 04;21(3):e48512. doi:10.15252/embr.201948512. Epub 2020 Jan 09
Jakub Ziak 1 , Romana Weissova 1 , Kateřina Jeřábková 2 , Martina Janikova 3 , Roy Maimon 4 , Tomas Petrasek 3 , Barbora Pukajova 1 , Marie Kleisnerova 5 , Mengzhe Wang 6 , Monika S Brill 6 , Petr Kasparek 2 , Xunlei Zhou 7 , Gonzalo Alvarez-Bolado 7 , Radislav Sedlacek 2 , Thomas Misgeld 8 , Ales Stuchlik 3 , Eran Perlson 4 , Martin Balastik 5
Jakub Ziak 1 , Romana Weissova 1 , Kateřina Jeřábková 2 , Martina Janikova 3 , Roy Maimon 4 , Tomas Petrasek 3 , Barbora Pukajova 1 , Marie Kleisnerova 5 , Mengzhe Wang 6 , Monika S Brill 6 , Petr Kasparek 2 , Xunlei Zhou 7 , Gonzalo Alvarez-Bolado 7 , Radislav Sedlacek 2 , Thomas Misgeld 8 , Ales Stuchlik 3 , Eran Perlson 4 , Martin Balastik 5
+ et al

[No authors listed]

Author information
  • 1 Faculty of Science, Charles University in Prague, Prague, Czech Republic.
  • 2 Department of Transgenic Models of Diseases and Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
  • 3 Department of Neurophysiology of the Memory, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
  • 4 Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • 5 Department of Molecular Neurobiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
  • 6 Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
  • 7 Institute of Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany.
  • 8 German Center for Neurodegenerative Diseases and Munich Cluster for Systems Neurology, Munich, Germany.

摘要


mice display ASD-related social behavior changes in the early postnatal period as well as in adults. Together, we demonstrate that CRMP2 mediates Sema3F-dependent synapse pruning and its dysfunction shares histological and behavioral features of ASD.

KEYWORDS: axon guidance, collapsin response mediator protein 2, dendritic spines, semaphorins, synapse pruning