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Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.

Nat Neurosci. 2020 Feb;23(2):172-175. Epub 2020 Jan 06
Simon Erlendsson 1 , Dustin R Morado 1 , Harrison B Cullen 2 , Cedric Feschotte 2 , Jason D Shepherd 3 , John A G Briggs 4
Simon Erlendsson 1 , Dustin R Morado 1 , Harrison B Cullen 2 , Cedric Feschotte 2 , Jason D Shepherd 3 , John A G Briggs 4
+ et al

[No authors listed]

Author information
  • 1 Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK.
  • 2 Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA.
  • 3 Department of Neurobiology and Anatomy, The University of Utah School of Medicine, Salt Lake City, Utah, USA.
  • 4 Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge, UK. jbriggs@mrc-lmb.cam.ac.uk.

摘要


Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.