Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins.
Nat Neurosci. 2020 Feb;23(2):172-175. Epub 2020 Jan 06
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摘要
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
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基因功能
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原始数据
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文献解读
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