例如："lncRNA", "apoptosis", "WRKY"

Possible Association of Elevated Plasma Levels of Growth Arrest-Specific Protein 6 and the Soluble Form of Tyrosine Kinase Receptor Axl with Low Hepatitis C Viral Load in Patients with Type 2 Diabetes Mellitus.

Viral Immunol. 2020 Mar;33(2):105-111. doi:10.1089/vim.2019.0127. Epub 2020 Jan 06
Rasha H Bassyouni 1 , Ahmed A Gomaa 2 , Essam A Hassan 2 , El Shaimaa Gomaa Ali 1 , Mahmoud A F Khalil 3 , Mohamed A Mashahit 4 , Sylvana N Gaber 1
Rasha H Bassyouni 1 , Ahmed A Gomaa 2 , Essam A Hassan 2 , El Shaimaa Gomaa Ali 1 , Mahmoud A F Khalil 3 , Mohamed A Mashahit 4 , Sylvana N Gaber 1
+ et al

[No authors listed]

Author information
  • 1 Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
  • 2 Department of Tropical Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
  • 3 Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.
  • 4 Department of Internal Medicine, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

摘要

This study aimed to investigate the plasma levels of Gas6 and soluble Axl (sAxl) in patients with chronic hepatitis C virus (HCV) infection with and without type 2 diabetes mellitus (T2DM). The study involved four groups; 50 patients with chronic HCV, 50 patients with T2DM, 50 patients with chronic HCV and T2DM, and 31 age- and sex-matched healthy controls. T2DM was diagnosed according to American Diabetes Association criteria, HCV antibodies were detected by enzyme-linked immunosorbent assays (ELISA) and confirmed by real-time-polymerase chain reaction. Plasma Gas6 and sAxl levels were assayed in all groups by ELISA. Significant low levels of GAS 6 in HCV/T2DM group versus HCV group were detected (7.92 ± 5.18 vs. 16.09 ± 7.36, respectively, p = 0.000), but higher than T2DM and control groups (p ≥ 0.05), although nonsignificant. HCV load was higher in the HCV group than the HCV/T2DM group (1,888,300 ± 5,595,070 vs. 1,417,900 ± 4,066,460 copies/mL, respectively, p = 0.632). Among HCV group, significant positive correlations were detected between Gas6 and sAxl levels with HCV viral load (r = 0.48, p = 0.000 and r = 0.43, p = 0.002, respectively), while among HCV/T2DM group, significant negative correlations were detected (r = -0.29, p = 0.04 and r = -0.34, p = 0.014, respectively). Significant negative correlations were detected between Gas6/sAxl levels and glycated hemoglobin (r = -0.36, p = 0.01 and r = -0.4, p = 0.003, respectively) in T2DM despite the positive correlations detected in HCV/T2DM (r = 0.27, p = 0.053 and r = 0.55, p = 0.000, respectively). In conclusion, Gas6/Axl system in combined HCV/T2DM diseases may affect the pathogenesis and can alter the biomarkers and complications of both diseases in a manner that differs from a solitary disease.

KEYWORDS: Gas6, diabetes mellitus, hepatitis C virus, sAxl

© 2017 biocloud.net版权所有 ICP证：京10042835号