[No authors listed]
Intracerebral hemorrhage (ICH) is a disease associated with high mortality and morbidity. MicroRNAs (miRNAs) have been reported to be associated with the pathogenesis of numerous cerebrovascular diseases, including ICH. miRâ222 has been revealed to play important roles in various physiological and pathological processes in cardiovascular diseases. However, its role in ICH remains largely unknown. The aim of the present study was to evaluate the potential effect of miRâ222 on brain injury in ICH. The results revealed that the expression of miRâ222 was significantly increased in ICH, and downregulation of miRâ222 significantly reduced erythrocyte lysateâinduced cell apoptosis by decreasing the levels of cleaved caspaseâ3, cleaved caspaseâ9 and Bax and increasing the level of Bclâ2. In addition, downregulation of miRâ222 suppressed the inflammatory responses in erythrocyte lysateâinduced microglia, and inhibited inflammation, brain water content and improved neurological functions in ICH mice. Mechanistically, integrin subunit β8 (ITGB8) was identified as a direct target of negative regulation by miRâ222 in microglia cells, and upâregulation of ITGB8 led to the attenuation of inflammation and apoptosis. Collectively, the present findings indicated that miRâ222 was a crucial regulator of inflammation via targeting of ITGB8, and represented a promising therapeutic strategy for ICH.
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