The roles of ADIPOQ rs266729 and MTNR1B rs10830963 polymorphisms in patients with gestational diabetes mellitus: A meta-analysis.

OBJECTIVES:This study aimed to investigate the roles of adiponectin (ADIPOQ) rs266729 and melatonin receptor 1B (MTNR1B) rs10830963 polymorphisms in patients with gestational diabetes mellitus (GDM). METHODS:The databases including Web of science, PubMed, Embase and Cochrane Library were searched for case-control studies updating on Feb 15th, 2019. 12 studies were finally included containing 3759 GDM patients and 4422 controls. The associations between two polymorphic sites (rs266729 and rs10830963) and GDM susceptibility were analyzed according to the pooled odds ratios (OR) and corresponding 95% confidence intervals (CI). RESULTS:Our pooled results indicated that ADIPOQ rs266729 can increase the GDM risk in Asian (dominant: GG+CG vs. CC, OR = 2.079, 95%CI: 1.012-4.270, P = 0.046) and European (allele: G vs. C, OR = 1.353, 95%CI: 1.001-1.829, P = 0.049 dominant: GG+CG vs. CC, OR = 1.522, 95%CI: 1.031-2.245, P = 0.034 heterozygote: CG vs. CC, OR = 1.517, 95%CI: 1.006-2.287, P = 0.047), but decrease in American population (allele: G vs. C, OR = 0.663, 95%CI: 0.501-0.878, P = 0.004 (dominant: GG+CG vs. CC, OR = 0.642, 95%CI: 0.456-0.903, P = 0.011 recessive: GG vs. CC+CG, OR = 0.496, 95%CI: 0.250-0.981, P = 0.044). The data demonstrated that the correlation between MTNR1B rs10830963 and GDM susceptibility is significant in Asian (allele: G vs. C, OR = 1.236, 95%CI: 1.109-1.378, P < 0.001 dominant: GG+CG vs. CC, OR = 1.285, 95%CI: 1.135-1.455, P < 0.001 recessive: GG vs. CC+CG, OR = 1.884, 95%CI: 1.307-2.716, P = 0.001 homozygote: GG vs. CC, OR = 1.514, 95%CI: 1.231-1.864, P < 0.001 heterozygote: CG vs. CC, OR = 1.198, 95%CI: 1.050-1.367, P = 0.007), and European (heterozygote: CG vs. CC, OR = 1.302, 95%CI: 1.011-1.677, P = 0.041). CONCLUSIONS:This Meta-analysis suggests that the variation of ADIPOQ rs266729 can increase the risk of GDM in Asian and European, while reduce in American population. Additionally, the association between MTNR1B rs10830963 and GDM susceptibility is significant in Asian, European and when using TaqMan assay.

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