Long non-coding RNA RBM5-AS1 promotes the aggressive behaviors of oral squamous cell carcinoma by regulation of miR-1285-3p/YAP1 axis.

The human genome encodes far more long non-coding RNA (lncRNA) genes than protein coding genes. However, the function of majority of the lncRNAs is poorly understood. Numerous lncRNAs were aberrantly expressed in various cancers and found to be associated with development and progression of cancer. Little is known about the role of lncRNAs in oral squamous cell carcinoma (OSCC). In this study, we identified lncRNA RBM5-AS1 to be highly expressed in OSCC tumor tissues and cancer cell lines. RBM5-AS1 promotes the proliferation, migration, and invasion of OSCC cells in vitro. We also found that RBM5-AS1 regulates the level of miR-1285-3p as a competitive endogenous RNA (ceRNA), therefore regulate the expression level of an oncogene-YAP1, a target of miR-1285-3p. The information obtained in this study is valuable for understanding the regulatory mechanism of lncRNA in the development of OSCC and for developing new strategies for the diagnosis and treatment of OSCC.

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