例如:"lncRNA", "apoptosis", "WRKY"

Host monitoring of quorum sensing during Pseudomonas aeruginosa infection.

Science. 2019 Dec 20;366(6472)
Pedro Moura-Alves 1 , Andreas Puyskens 2 , Anne Stinn 3 , Marion Klemm 2 , Ute Guhlich-Bornhof 2 , Anca Dorhoi 4 , Jens Furkert 5 , Annika Kreuchwig 5 , Jonas Protze 5 , Laura Lozza 6 , Gang Pei 2 , Philippe Saikali 2 , Carolina Perdomo 2 , Hans J Mollenkopf 7 , Robert Hurwitz 8 , Frank Kirschhoefer 9 , Gerald Brenner-Weiss 8 , January Weiner 2 , Hartmut Oschkinat 5 , Michael Kolbe 3 , Gerd Krause 5 , Stefan H E Kaufmann 10
Pedro Moura-Alves 1 , Andreas Puyskens 2 , Anne Stinn 3 , Marion Klemm 2 , Ute Guhlich-Bornhof 2 , Anca Dorhoi 4 , Jens Furkert 5 , Annika Kreuchwig 5 , Jonas Protze 5 , Laura Lozza 6 , Gang Pei 2 , Philippe Saikali 2 , Carolina Perdomo 2 , Hans J Mollenkopf 7 , Robert Hurwitz 8 , Frank Kirschhoefer 9 , Gerald Brenner-Weiss 8 , January Weiner 2 , Hartmut Oschkinat 5 , Michael Kolbe 3 , Gerd Krause 5 , Stefan H E Kaufmann 10
+ et al

[No authors listed]

Author information
  • 1 Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK.
  • 2 Department of Immunology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
  • 3 Faculty of Mathematics, Informatics and Natural Sciences, University of Hamburg, 20148 Hamburg, Germany.
  • 4 Faculty of Mathematics and Natural Sciences, University of Greifswald, Greifswald, Germany.
  • 5 Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
  • 6 Epiontis GmbH-Precision for Medicine, 12489 Berlin, Germany.
  • 7 Microarray Core Facility, Max Planck Institute for Infection Biology, Department of Immunology, 10117 Berlin, Germany.
  • 8 Protein Purification Core Facility, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
  • 9 Institute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany.
  • 10 Hagler Institute for Advanced Study at Texas A&M University, College Station, TX 77843, USA.

摘要


Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses to collectively modify its behavior through the production, release, and detection of signaling molecules. QS molecules can also be sensed by hosts, although the respective receptors and signaling pathways are poorly understood. We describe a pattern of regulation in the host by the aryl hydrocarbon receptor (AhR) that is critically dependent on qualitative and quantitative sensing of P. aeruginosa quorum. QS molecules bind to AhR and distinctly modulate its activity. This is mirrored upon infection with P. aeruginosa collected from diverse growth stages and with QS mutants. We propose that by spying on bacterial quorum, AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to the status quo of infection.