Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.

Nat Neurosci. 2020 Jan;23(1):15-20. Epub 2019 Dec 16

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Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H₂O₂). We show that MAO metabolism of DA does not increase cytosolic H₂O₂ but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.

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Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain.

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