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Filaggrin gene mutations in relation to contact allergy and hand eczema in adolescence.

Contact Derm.2020 Mar;82(3):147-152. doi:10.1111/cod.13444. Epub 2019 Dec 22
Maria Lagrelius 1 , Carl-Fredrik Wahlgren 2 , Maria Bradley 2 , Erik Melén 3 , Inger Kull 3 , Anna Bergström 1 , Carola Lidén 4
Maria Lagrelius 1 , Carl-Fredrik Wahlgren 2 , Maria Bradley 2 , Erik Melén 3 , Inger Kull 3 , Anna Bergström 1 , Carola Lidén 4
+ et al

[No authors listed]

Author information
  • 1 Region Stockholm, Centre for Occupational and Environmental Medicine, Stockholm, Sweden.
  • 2 Karolinska University Hospital, Stockholm, Sweden.
  • 3 Sachs' Children's Hospital, Stockholm, Sweden.
  • 4 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

摘要


BACKGROUND:Filaggrin is an important protein for structure and function of the skin barrier. Filaggrin gene (FLG) mutations are known to result in dry skin, impaired skin barrier, and increased risk for atopic dermatitis. However, it is not clear whether these mutations are associated with contact allergy or hand eczema in adolescence. OBJECTIVES:The purpose of this study was to investigate whether FLG mutations are associated with contact allergy, self-reported hand eczema, or dry skin in adolescence. METHODS:We used data from the 16-year follow-up in the BAMSE cohort, information obtained from a Web-based questionnaire including questions on hand eczema and dry skin, from FLG mutation analysis (R501X, R2447X, 2282del4), and patch testing (n = 1822). RESULTS:Logistic regression analyses showed no statistically significant associations between FLG mutations and contact allergy (any contact allergy, nickel allergy, or fragrance allergy) according to patch test, or self-reported hand eczema at 16 years, or hand eczema ever. However, FLG mutations were associated with self-reported dry skin at 16 years. CONCLUSIONS:FLG mutations are associated with self-reported dry skin at 16 years. However, in this study no consistent associations were found between FLG mutations and contact allergy or hand eczema at 16.

KEYWORDS: adolescent, contact allergy, dry skin, epidemiology, filaggrin, fragrance, hand eczema, nickel