Expression of La Ribonucleoprotein Domain Family Member 4B (LARP4B) in Liver Cancer and Their Clinical and Prognostic Significance.

BACKGROUND AND OBJECTIVE:Liver cancer is a common malignant tumor with few poor diagnostic and prognostic markers, which greatly shortens the potential life span of patients. The RNA-binding protein la ribonucleoprotein 4B has a la motif (lam) that is important in the process of cancer. We aimed to explore the role of in the diagnosis and prognosis of liver cancer. METHODS:The Cancer Genome Atlas (TCGA) database was searched to detect gene expression in liver cancer. The clinical relevance and diagnostic ability of Lduanyu374B were evaluated by a chi-squared test and a receiver operating characteristic (ROC) curve, respectively. Survival and risk factors of patients with liver cancer were assessed by survival analysis and univariate/multivariate Cox regression model. Additionally, we carried out gene set enrichment analysis (GSEA) to identify signaling pathways in liver mRNA was highly expressed in liver cancer tissues and was correlated with survival status. The chi-squared test showed that Lduanyu374B had clinical relevance, while ROC curves showed that Lduanyu374B had good diagnostic ability. Survival analysis showed that liver cancer patients with high Lduanyu374B expression had shorter overall/relapse-free survival. The univariate/multivariate Cox regression model indicated that high Lduanyu374B expression may be an independent risk factor for the prognosis of liver cancer patients. Finally, we found that genes involved in the G2M checkpoint, E2F targets, and mitotic spindle were differentially enriched in the high is a potential independent biomarker for diagnosis and prognosis in liver cancer patients.

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