[No authors listed]
Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is regulated by a variety of intracellular regulatory factors including osterix, runtârelated transcription factor 2 (RUNX2), bone morphogenetic proteins and transforming growth factorβ. Recent studies have shown that microRNAs (miRs) serve a crucial role in this process. In the present study, miRâ483â3p levels were significantly increased during osteogenic differentiation of mouse and human BMSCs. Overexpression of miRâ483â3p promoted osteogenic differentiation, whereas inhibition of miRâ483â3p reversed these effects. miRâ483â3p regulated osteogenic differentiation of BMSCs by targeting and thus enhancing RUNX2 transcriptional activity and RUNX2 nuclear translocation. In vivo, overexpression of miRâ483â3p using a BMSCâspecific aptamer delivery system stimulated bone formation in aged mice. Therefore, the present study suggested that miRâ483â3p promoted osteogenic differentiation of BMSCs by targeting duanyu18131, and miRâ483â3 prepresent a potential therapeutic target for ageârelated bone loss.
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