Hydrogen peroxide in the ER: A tale of triage.

Oxidative protein folding in the endoplasmic reticulum (ER) is a significant source of hydrogen peroxide (H₂O₂). For correct protein folding the redox state of the ER must be efficiently regulated. As such, several mechanisms with varying degrees of overlap manage the redox state of the ER. H₂O₂ also functions as a second messenger playing a role in most aspects of cellular physiology and pathology, requiring tight control of the concentration and flux of H₂O₂. Bestetti et al. have demonstrated a role for Aquaporin 11 in transport of H₂O₂ out of the ER.

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