Structural basis of temperature sensation by the TRP channel TRPV3.

Nat Struct Mol Biol. 2019 Nov;26(11):994-998. Epub 2019 Oct 21

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We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo Î±-to-Ï transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.

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Structural basis of temperature sensation by the TRP channel TRPV3.

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