The diagnosis values of serum STAT4 and sEng in preeclampsia.

OBJECTIVE:To detect the levels of signal transducer and activator of transcription 4 and soluble endoglin (sEng) in preeclampsia patients and analyze the diagnostic values of and sEng in preeclampsia. METHODS:Fifty-four pregnant women with preeclampsia from October 2017 to June 2018 were included in this study. Twenty-eight matched healthy pregnant women were set as the control group. The general clinical characteristics were measured. Serum duanyu18134 and sEng were detected by ELISA. Correlation between duanyu18134 and sEng, and their diagnostic value in preeclampsia were analyzed. RESULTS:Compared with control, the prothrombin time in preeclampsia was significantly lower, while the mean arterial pressure, 24-hour urine protein, serum creatinine, fibrinogen, and ALT were significantly higher. The circulating levels of duanyu18134 and sEng were significantly increased in the preeclampsia. The serum levels of duanyu18134 and sEng in preeclampsia were positively correlated. For the diagnosis of preeclampsia by the serum AUC is 0.902, and the sensitivity and specificity are 0.893 and 0.929. By the serum sEng, AUC is 0.873, and the sensitivity and specificity are 0.816 and 0.905. CONCLUSION:The serum levels of duanyu18134 and sEng were significantly increased in preeclampsia with disease severity status, which have promise as diagnostic markers in preeclampsia.

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