例如:"lncRNA", "apoptosis", "WRKY"

Induction of co-inhibitory molecule CTLA-4 by human papillomavirus E7 protein through downregulation of histone methyltransferase JHDM1B expression.

Virology. 2019 Dec;538:111-118. Epub 2019 Oct 02
Qiang Zhou 1 , Luxia Chen 1 , Yinjing Song 1 , Li Ma 1 , Peng Xiao 2 , Lingjing Chen 1 , Huimin Zhen 3 , Rui Han 1 , Xianzhen Chen 1 , Siyuan Sun 1 , Tuan Wang 1 , Boya Zhang 1 , Qingqing Wang 4 , Hao Cheng 5
Qiang Zhou 1 , Luxia Chen 1 , Yinjing Song 1 , Li Ma 1 , Peng Xiao 2 , Lingjing Chen 1 , Huimin Zhen 3 , Rui Han 1 , Xianzhen Chen 1 , Siyuan Sun 1 , Tuan Wang 1 , Boya Zhang 1 , Qingqing Wang 4 , Hao Cheng 5
+ et al

[No authors listed]

Author information
  • 1 Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, Zhejiang, PR China.
  • 2 Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, PR China.
  • 3 Department of Dermatology, Lin Hai First People's Hospital, Taizhou, 318020, Zhejiang, PR China.
  • 4 Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310058, Zhejiang, PR China. Electronic address: wqq@zju.edu.cn.
  • 5 Department of Dermatology and Venereology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, Zhejiang, PR China. Electronic address: chenghao1@zju.edu.cn.

摘要


Human papillomavirus causes various skin diseases and even cancer. Unfortunately, the host immune system often fails to generate effective responses against HPV infection due to the ability of HPV to evade immune-mediated eradication, although the detailed mechanisms by which HPV inhibits host antiviral immunity are not fully understood. In this study, we reported a novel role of HPV E7 oncoprotein in inducing the expression of co-inhibitory molecule cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) in cells of epithelial origin. Mechanistically, HPV E7 protein downregulated the cellular abundance of Jumonji C histone demethylase 1B (JHDM1B), increasing the levels of H3K36 methylation within the promoter region of CTLA-4. Our findings expand the current understanding of HPV-mediated immune evasion mechanisms and may be helpful in developing optimal anti-HPV therapeutic strategies and relevant drugs.

KEYWORDS: Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), Human papillomavirus E7, Jumonji C histone demethylase1B (JHDM1B)