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Association between MSX1 rs12532 polymorphism with nonsyndromic unilateral complete cleft lip and palate and tooth agenesis.

Arch. Oral Biol.2020 Jan;109:104556. Epub 2019 Sep 17
Melissa Lancia 1 , Renato Assis Machado 2 , Thiago José Dionísio 3 , Daniela Gamba Garib 4 , Carlos Ferreira Dos Santos 5 , Ricardo D Coletta 6 , Lucimara Teixeira das Neves 7
Melissa Lancia 1 , Renato Assis Machado 2 , Thiago José Dionísio 3 , Daniela Gamba Garib 4 , Carlos Ferreira Dos Santos 5 , Ricardo D Coletta 6 , Lucimara Teixeira das Neves 7
+ et al

[No authors listed]

Author information
  • 1 Department of Orthodontics, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil.
  • 2 Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Bauru, São Paulo, Brazil.
  • 3 Laboratory Specialist, Department of Biological Sciences, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil.
  • 4 Department of Orthodontics, Bauru Dental School, University of São Paulo, Post-Graduation Program in Rehabilitation Sciences, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Bauru, São Paulo, Brazil.
  • 5 Department of Biological Sciences, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil.
  • 6 Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil.
  • 7 Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Post-Graduation Program in Rehabilitation Sciences, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Bauru, São Paulo, Brazil. Electronic address: lucimaraneves@fob.usp.br.

摘要

OBJECTIVES:To investigate the association of MSX1 rs12532 polymorphism with the risk of nonsyndromic unilateral complete cleft lip and palate (NSCLP) and tooth agenesis. MATERIALS AND METHODS:The study is comprised of 384 individuals divided into 4 groups: group 1, patients with unilateral complete NSCLP and premolar agenesis (n = 57); group 2, patients with unilateral NSCLP without tooth agenesis (n = 117); group 3, patients with premolar agenesis without oral cleft (n = 53) and group 4 (n = 157), a control group with individuals without tooth agenesis and oral cleft. Genotyping of rs12532 was carried out with Taqman chemistry, and associations were investigated using logistic regression analyses. RESULTS:Overall rs12532 allele and genotype distributions revealed no significant differences between the groups of NSCLP or tooth agenesis. CONCLUSION:Although our results are consistent with a lack of association of MSX1 rs12532 and the risk of unilateral NSCLP and tooth agenesis, further studies with additional SNPs and a more diverse ethnic cohort are warranted.

KEYWORDS: MSX1, Nonsyndromic cleft lip and palate, Risk factor, Single nucleotide polymorphism, Tooth agenesis

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