Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder.

J Neural Transm (Vienna). 2019 Dec;126(12):1707-1711. Epub 2019 Sep 27

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摘要

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (nâ=â146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (nâ=â64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.

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Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder.

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