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Expression of miR-29 and STAT3 in osteosarcoma and its effect on proliferation regulation of osteosarcoma cells.

Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7275-7282. doi:10.26355/eurrev_201909_18832
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摘要


has been shown to be involved in the occurrence, progression, and resistance of various tumors. The abnormal expression of miR-29 is associated with the pathogenesis of osteosarcoma. The bioinformatics analysis showed a targeting relationship between miR-29 and 3'-UTR. This study investigated whether miR-29 regulates the duanyu18133 expression and affects the proliferation and apoptosis of osteosarcoma cells. PATIENTS AND METHODS:The tumor tissues of osteosarcoma patients were collected, and the adjacent tissues were used as controls to detect the expression of miR-29 and The Dual-Luciferase Gene Reporter Assay validated the regulatory relationship between miR-29 and duanyu18133. The expression of miR-29 and duanyu18133 in normal osteoblasts hFOB1.19, osteosarcoma SJSA-1, and MG-63 was measured. SJSA-1 cells were divided into miR-NC group and miR-29 mimic group. Cell apoptosis and proliferation were detected by flow cytometry. RESULTS:Compared with adjacent tissues, miR-29 expression was decreased, and duanyu18133 expression was increased in osteosarcoma. There was a targeted regulation relationship between miR-29 and duanyu18133. Compared with hFOB1.19 cells, miR-29 expression in osteosarcoma SJSA-1 and MG-63 cells was decreased, with increased duanyu18133 expression. The transfection of miR-29 mimic significantly decreased the expression of duanyu18133 and in SJSA-1 cells, inhibited cell proliferation, and increased cell apoptosis. CONCLUSIONS:Decreased miR-29 expression plays a role in the increase of the duanyu18133 expression and in the promotion of the pathogenesis of osteosarcoma. Increasing the expression of miR-29 can inhibit the proliferation of osteosarcoma cells and promote apoptosis by decreasing duanyu18133 expression.

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