Clinical important dysregulation of long non-coding RNA CCHE1 and HULC in carcinogenesis of cervical cancer.

Genetic analysis has revealed that the lncRNAs acted in the critical pathways including cell growth, cell differentiation, and tumorigenesis. The purpose of the present survey was to evaluate the lncRNA-CCHE1 and lncRNA-HULC expression variations in subjects with cervical malignancy. In our case-control analysis planned on 100 formalin-fixed paraffin-embedded (FFPE) samples comprising 50 paraffin blocks of cervical cancerous and 50 paraffin blocks of non-tumors samples. We have calculated the lncRNA-CCHE1 and lncRNA-HULC gene expression alterations using a quantitative RT-PCR approach. Our results declared that the lncRNA-CCHE1 expression was considerably raised in tumorous matched to the non-tumorous samples (P = 0.001). Moreover, the lncRNA-HULC expression was not considerably modified between tumorous samples matched to the non-tumorous samples (P = 0.060). In extension, lncRNA-CCHE1 expression variation was correlated with the histological type (P = 0.001), tumor size (P = 0.001) and FIGO stage (P = 0.001). Our data advised that the lncRNA-CCHE1 gene may influence cervical malignancy progression, held as a prognostic marker and useful curative target. However, the character of lncRNA-HULC in carcinogenesis of cervical malignancy requires further analyses.

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