TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer.

a member of the tetraspanin family, has been highly connected with the pathogenesis of cancer. Its biological function, however, especially in ovarian cancer (OC), has not been well elucidated. In this study, The Cancer Genome Atlas (TCGA) dataset analysis revealed that upregulation of gene expression was significantly correlated with patient survival, suggesting that might be a potential prognostic marker for OC. Further exploration showed that Tduanyu1842N12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. Knockdown of Tduanyu1842N12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. Western blot analysis showed that several cyclins and cyclin-dependent kinases (CDK) (e.g., Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of Moreover, Tduanyu1842N12 accelerated mitotic progression by controlling cell cycle. Thus, our data demonstrated that Tduanyu1842N12 could be a novel molecular target for the treatment of OC.

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