Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.

Theranostics. 2019 May 31;9(13):3903-3917. eCollection 2019

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: Cathepsin B is actively involved in the effector phase of acute cutaneous DTHR. Thus, topically applied cathepsin B inhibitors might effectively limit DTHR such as contact dermatitis or psoriasis. However, the cathepsin B and Z knockout mouse experiments suggested a complementary role for these two cysteine-type proteases.

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Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions.

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