Evidence on the direct correlation between miR-31 and IL-22 axis in IMQ-induced psoriasis.

Psoriatic skin is characterized by a deregulated profile of miRNAs that are contributing in disease development. In this study, we focus on miR-31, one of the upregulated miRNAs known to promote keratinocytes proliferation and migration. Moreover, miR-31 expression induction was dependent on a large panel of cytokines including IL-22. Here, we aimed at investigating the relationship between miR-31-5p and IL-22 axis; and by searching novel molecular target for miR-31-5p in keratinocytes. Our data identify a direct correlation between miR-31-5p and IL-22 in psoriasis with Pwp1 as new potential target. These findings confirm the important role of miR-31 in psoriasis onset and provide a basis for further investigations in miRNAs field in context of skin diseases.

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