RETRACTED: Serine/threonine kinase BUB1 promotes proliferation and radio-resistance in glioblastoma.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The article has been retracted for the following reasons: The authors have informed the journal that in the published version, the authors showed that that BUB1 inhibitor confers higher cell killing effect for irradiation treatment. This conclusion was based on two experimental evidences. First, the irradiation treatment showed greater cytotoxicity for in vitro cell growth when combined with BUB1 inhibitor. Second, the FACS data showed that the combination of irradiation and BUB1 inhibitor induced significantly higher apoptosis rate of GBM tumor cells, in comparison with irradiation alone. After the acceptance of the article, the authors reported that they found that it was hard to obtain the same result for the cell apoptosis experiment. Because of the doubtful result, the authors currently do not have enough evidence to support the conclusion (the combination of BUB1 inhibition and irradiation is a potential clinical strategy). However, the overall purpose of this manuscript is to identify potential therapeutic target for GBM and as it stands it may mislead other researchers.

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