Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors.

Sci Rep. 2019 Jun 19;9(1):8762

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Thymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting in eosinophilic inflammation and numerous allergic diseases. Baicalein (1), a major component of Scutellaria baicalensis, was found to be the first small molecule to block TSLP signaling pathways. It inhibited effectively eosinophil infiltration in house dust mite-induced and ovalbumin-challenged mouse models. Structure-activity relationship studies identified compound 11a, a biphenyl flavanone analog, as a novel human TSLP inhibitor for the discovery and development of new anti-allergic drugs.

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Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors.

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