Constant expression of somatostatin receptor 2a in minute pulmonary meningothelial-like nodules.

AIMS:Although ultrastructural studies showed that minute pulmonary meningothelial-like nodules cells closely resembled meningothelial cells, their immunophenotype has not been well characterised, partly due to their rarity. METHODS:Somatostatin receptor 2a and other markers of meningioma, including epithelial membrane antigen (EMA), progesterone receptor (PR) and S100, were analysed retrospectively in 19 cases from two institutions in China. RESULTS:The median age of patients with was 62.5 years (32-73 years), with a male-to-female ratio of 1:8.5. Most (15/19) patients with Mduanyu1451s had coexisting diseases, including adenocarcinomas (12 cases), bronchiectasis (1 case) and tuberculosis (2 cases). Just over half of the cases (10/19) were multifocal lesions (2-5 lesions). An additional 53 cases with 123 lesions from the literature were reviewed with reported immunophenotype information. In total, 162 lesions were included in the analysis. The size of nodules was 1-4 mm. All Mduanyu1451 lesions (39/39) in the 19 cases showed strong and diffuse cytoplasmic expression of The expression rate of was higher than that of conventional markers of meningioma, including EMA (86/138), PR (32/68) and S100 (1/125). CONCLUSIONS:Our observations expand the spectrum of recognised lesions and once again demonstrated that Mduanyu1451s show immunohistochemical characteristics similar to meningothelial cells.

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