SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function.

Myeloid-derived suppressor cells (MDSC) can suppress immunity and promote tumorigenesis, and their abundance is associated with poor prognosis. In this study, we show that SUMO1/sentrin-specific peptidase 1 (SENP1) regulates the development and function of MDSC. SENP1 deficiency in myeloid cells promoted MDSC expansion in bone marrow, spleen, and other organs. Senp1 MDSC showed stronger immunosuppressive activity than Senp1 MDSC; we observed no defects in the differentiation of myeloid precursor cell in Senp1 mice. Mechanistically, SENP1-mediated regulation of MDSC was dependent on signaling. We identified CD45 as a specific duanyu18133 phosphatase in MDSC. CD45 was SUMOylated in MDSC and SENP1 could deconjugate SUMOylated CD45. In Senp1 MDSC, CD45 was highly SUMOylated, which reduced its phosphatase activity toward leading to MDSC development and function. These results reveal a suppressive function of SENP1 in modulating MDSC expansion and function via signaling axis. SIGNIFICANCE: These findings show that increased SUMOylation of CD45 via loss of SENP1 suppresses CD45-mediated dephosphorylation of duanyu18133, which promotes MDSC development and function, leading to tumorigenesis.

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