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Decreased number of CD19+CD24hiCD38hi regulatory B cells in Diabetic nephropathy.

Mol. Immunol.2019 Aug;112:233-239. Epub 2019 Jun 07
Tao Li 1 , Zhenxiang Yu 2 , Zhihui Qu 3 , Nan Zhang 4 , Rebecca Crew 5 , Yanfang Jiang 6
Tao Li 1 , Zhenxiang Yu 2 , Zhihui Qu 3 , Nan Zhang 4 , Rebecca Crew 5 , Yanfang Jiang 6
+ et al

[No authors listed]

Author information
  • 1 Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: litao199210241@126.com.
  • 2 Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: yuzhenxiang2005@sina.com.
  • 3 Department of Nephrology, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: quzhih777@sina.cn.
  • 4 Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: susanna1207@126.com.
  • 5 University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Electronic address: Rebecca-Crew@ouhsc.edu.
  • 6 Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonoses Research, Ministry of Education, The First Hospital of Jilin University, Changchun 130021, China; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing, China. Electronic address: yanfangjiang@jlu.edu.cn.

摘要

BACKGROUND:Regulatory B cells participate in the pathogenesis of autoimmune disease. This study aimed to examine the putative contribution of regulatory B cells to the pathogenesis of DN. The number of circulating CD19+CD24hiCD38hi B cells, CD19+CD24hiCD38hiCD5+ B cells, and CD19+CD24hiCD38hiIL-10+ B cells were significantly lower in DN patients (p < 0.05) than the control group. The number of circulating CD19+CD24hiCD38hi B cells was positively correlated with the levels of eGFR and serum IL-10 levels, but negatively correlated with urinary protein levels in DN patients. Treatment significantly increased the number of CD19+CD24hiCD38hi B cells, CD19+CD24hiCD38hiCD5+ B cells, CD19+CD24hiCD38hiIL-10+ B cells, and the levels of serum IL-10 (p < 0.05). We conclude that regulatory B cells may present new targets for intervention of DN.

KEYWORDS: Diabetic nephropathy, IL-10, Regulatory B cells, Urinary protein, eGFR

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