[No authors listed]
Prostate cancer is one of the most common human malignancies, which represents a serious threat to health, and microRNAs (miRNAs/miRs) have been reported to be closely associated with the progression and development of prostate cancer. The present study aimed to investigate the expression patterns, functions and underlying mechanisms of miRâ589â5p in prostate cancer. The results demonstrated that the expression levels of miRâ589â5p were downregulated in prostate cancer tissues and cell lines. Overexpression of miRâ589â5p inhibited cell viability, migration and invasion in prostate cancer cells. Subsequently, chemokine (CâC motif) ligand 5 (CCLâ5) was identified as a direct target gene of miRâ589â5p, which was highly expressed at the mRNA and protein levels in prostate cancer tissues and cells. Furthermore, CCLâ5 mRNA was negatively correlated with miRâ589â5p expression in prostate cancer tissues. Silencing CCLâ5 promoted the apoptosis, and inhibited the migration and invasion of prostate cancer cells. Taken together, these results indicated that miRâ589â5p may act as a tumor suppressor in prostate cancer by targeting CCLâ5, thus suggesting that miRâ589â5p may be a novel and reliable molecular marker for the diagnosis and prognosis of prostate cancer.
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