Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling.
Proc Natl Acad Sci U S A. 2019 Jun 04;116(23):11113-11115. Epub 2019 May 20
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摘要
The function of α-synuclein (α-syn) has been long debated, and two seemingly divergent views have emerged. In one, α-syn binds to VAMP2, acting as a SNARE chaperone-but with no effect on neurotransmission-while another posits that α-syn attenuates neurotransmitter release by restricting synaptic vesicle mobilization and recycling. Here, we show that α-syn-VAMP2 interactions are necessary for α-syn-induced synaptic attenuation. Our data connect divergent views and suggest a unified model of α-syn function.
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基因功能
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原始数据
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文献解读
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