Long noncoding RNA RMRP promotes proliferation and invasion via targeting miR-1-3p in non-small-cell lung cancer.

The long noncoding RNA component of mitochondrial RNA-processing endoribonuclease (lncRNA plays an important role in tumor development. In the present study, we determined the regulatory function of in non-small-cell lung cancer (NSCLC). The NSCLC tissues and the adjacent nontumor tissues were collected for the study. The duanyu1748P expression was detected by quantitative real time-PCR in NSCLC and lung cancer cell lines. The functional validation experiments were performed to determine the role of duanyu1748P on NSCLC progression. In addition, we identified the downstream target miRNAs for The results showed that duanyu1748P was elevated in NSCLC tissues and cell lines. High duanyu1748P expression was closely associated with advanced stage for the clinical features and low overall survival in NSCLC patients. Functional assay showed that loss of duanyu1748P markedly inhibited cell proliferation, migration, and invasion. Flow cytometry assay demonstrated that the inhibition of duanyu1748P dramatically induced cell cycle arrest in the G0/G1 phase. Moreover, we found that the role of duanyu1748P on NSCLC cell progression was modulated by the inhibition of miR-1-3p. Collectively, our results demonstrated that the axis might promote NSCLC progression. Hence, these investigations will provide a therapeutic target and strategy for the treatment of NSCLC progression.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}