Effects of MTNR1B Genetic Variants on Individual Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis.

OBJECTIVE:Whether melatonin receptor 1B (MTNR1B) variants are implicated in gestational diabetes mellitus (GDM) remains unclear. Therefore, we performed this meta-analysis to obtain a more conclusive result on associations between MTNR1B variants and GDM. STUDY DESIGN:Literature research was performed in PubMed, Web of Science, Embase, and China National Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS:A total of 17 studies were eligible for analyses. Pooled overall analyses showed that rs1387153 (dominant model: p = 0.0002, OR = 0.78, 95% CI: 0.68-0.89; recessive model: p < 0.0001, OR = 1.46, 95% CI: 1.24-1.73; allele model: p < 0.0001, OR = 0.78, 95% CI: 0.72-0.84), rs4753426 (recessive model: p = 0.01, OR = 1.75, 95% CI: 1.14-2.68; allele model: p = 0.01, OR = 0.69, 95% CI: 0.51-0.93), and rs10830963 (dominant model: p < 0.0001, OR = 0.72, 95% CI: 0.65-0.78; recessive model: p < 0.0001, OR = 1.56, 95% CI: 1.40-1.74; allele model: p < 0.0001, OR = 0.73, 95% CI: 0.69-0.78) variants were all significantly associated with the susceptibility to GDM. Further subgroup analyses by ethnicity of participants yielded similar positive results. CONCLUSION:Our findings indicated that MTNR1B rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM.

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