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Effects of MTNR1B Genetic Variants on Individual Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis.

Am J Perinatol. 2020 May;37(6):607-612. doi:10.1055/s-0039-1685446. Epub 2019 Apr 16
Guangliang Jia 1 , Yanxiang Gao 2 , Chunzhi Li 3 , Yanqin Zhang 4
Guangliang Jia 1 , Yanxiang Gao 2 , Chunzhi Li 3 , Yanqin Zhang 4

[No authors listed]

Author information
  • 1 Department of Rehabilitation Medicine, Changyi People's Hospital, Changyi, Shandong, China.
  • 2 Department of Cardiothoracic Surgery, Changyi People's Hospital, Changyi, Shandong, China.
  • 3 Department of Infectious Disease, Changyi People's Hospital, Changyi, Shandong, China.
  • 4 Department of Nursing, Yulin Traditional Chinese Medicine Hospital, Yulin, Shanxi, China.

摘要


OBJECTIVE:Whether melatonin receptor 1B (MTNR1B) variants are implicated in gestational diabetes mellitus (GDM) remains unclear. Therefore, we performed this meta-analysis to obtain a more conclusive result on associations between MTNR1B variants and GDM. STUDY DESIGN:Literature research was performed in PubMed, Web of Science, Embase, and China National Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. RESULTS:A total of 17 studies were eligible for analyses. Pooled overall analyses showed that rs1387153 (dominant model: p = 0.0002, OR = 0.78, 95% CI: 0.68-0.89; recessive model: p < 0.0001, OR = 1.46, 95% CI: 1.24-1.73; allele model: p < 0.0001, OR = 0.78, 95% CI: 0.72-0.84), rs4753426 (recessive model: p = 0.01, OR = 1.75, 95% CI: 1.14-2.68; allele model: p = 0.01, OR = 0.69, 95% CI: 0.51-0.93), and rs10830963 (dominant model: p < 0.0001, OR = 0.72, 95% CI: 0.65-0.78; recessive model: p < 0.0001, OR = 1.56, 95% CI: 1.40-1.74; allele model: p < 0.0001, OR = 0.73, 95% CI: 0.69-0.78) variants were all significantly associated with the susceptibility to GDM. Further subgroup analyses by ethnicity of participants yielded similar positive results. CONCLUSION:Our findings indicated that MTNR1B rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM.