ATP Inhibits the Transcription Factor STAT5b.

Although naturally occurring low-molecular-weight compounds have many known roles within the cell, these do not usually involve the direct inhibition of protein-protein interactions. Based on the results of high-throughput screening of a library of bioactive compounds and neurotransmitters, we report here that the four nucleoside triphosphates ATP, GTP, CTP and UTP inhibit the SH2 domain of the tumor-related transcription factor ATP and GTP are the most active nucleoside triphosphates and show specificity for over and the p53-binding protein HDM2. As the inhibition constant of ATP against duanyu18135b is significantly lower than published values for the intracellular ATP concentration, our data suggest that ATP might inhibit the protein-protein interactions of duanyu18135b in living cells.

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