BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection.
Front Immunol. 2019 Mar 29;10:617. doi:10.3389/fimmu.2019.00617. eCollection 2019
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摘要
B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV infection.
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基因功能
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文献解读
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