Stepping out of the shadow: STIM2 promotes IL-3-induced cytokine release.
Sci Signal. 2019 Apr 09;12(576)
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摘要
Basophils are a small population of innate immune cells, but their release of the cytokine interleukin-4 (IL-4) is important for mounting an efficient immune response against distinct parasites. Yoshikawa et al (in the 9 April 2019 issue) showed that whereas STIM1 is essential for IL-4 release after stimulation of FcεRI, STIM2 mediates a delayed IL-3/IL-33-induced IL-4 release independent of STIM1.
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文献解读
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