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Increased CD8+CD27+perforin+ T cells and decreased CD8+CD70+ T cells may be immune biomarkers for aplastic anemia severity.

Blood Cells Mol. Dis.2019 Jul;77:34-42. Epub 2019 Mar 30
Suwen Zhao 1 , Yuping Zhang 2 , Guixuan Huang 3 , Weifeng Luo 4 , Yan Li 5 , Yankai Xiao 1 , Ming Zhou 2 , Yumiao Li 2 , Jing Lai 6 , Yangqiu Li 7 , Bo Li 8
Suwen Zhao 1 , Yuping Zhang 2 , Guixuan Huang 3 , Weifeng Luo 4 , Yan Li 5 , Yankai Xiao 1 , Ming Zhou 2 , Yumiao Li 2 , Jing Lai 6 , Yangqiu Li 7 , Bo Li 8
+ et al

[No authors listed]

Author information
  • 1 Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China.
  • 2 Department of Hematology, Guangzhou First Municipal People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, China.
  • 3 Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China.
  • 4 Guangzhou Blood Center, Guangzhou, China.
  • 5 Department of Cardiology, First Affiliated Hospital, Jinan University, Guangzhou, China.
  • 6 Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China.
  • 7 Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China; Department of Hematology, First Affiliated Hospital, Jinan University, Guangzhou, China. Electronic address: yangqiuli@hotmail.com.
  • 8 Key Laboratory for Regenerative Medicine of Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China. Electronic address: libo517@jnu.edu.cn.

摘要

OBJECTIVES:Aplastic anemia (AA) is T cell immune-mediated autoimmune disease. Aberrant T cell activation involves an imbalance in T cell homeostasis in AA. However, whether the T cell activation molecule CD27 and its ligand CD70 participate in the immune pathogenesis of AA remains ill defined. METHODS:The frequencies of CD27/CD70 and perforin/granzyme B in different T cell subsets were detected in AA patients and healthy individuals by flow cytometry. RESULTS:We first time demonstrate a significantly elevated proportion of CD27+ and significantly decreased CD70+ T cells from AA. Changed frequency of CD27+ and CD70+ in different T cell subsets appeared to be associated with AA severity. In very severe aplastic anemia (VSAA) and severe aplastic anemia (SAA), increased CD8+CD27+ T cells present with a cytotoxic effector phenotype by elevating perforin proportion. CONCLUSIONS:Elevated proportion of CD27 in T cells may contribute to distinct immune pathogenesis for different severities of AA. The CD8+CD27+perforin+ T cells combined with CD8+CD70+ T cells may serve as an immune biomarker for AA severity estimation.

KEYWORDS: Aplastic anemia, CD27, CD70, Perforin

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