Increased CD8⁺CD27⁺perforin⁺ T cells and decreased CD8⁺CD70⁺ T cells may be immune biomarkers for aplastic anemia severity.

OBJECTIVES:Aplastic anemia (AA) is T cell immune-mediated autoimmune disease. Aberrant T cell activation involves an imbalance in T cell homeostasis in AA. However, whether the T cell activation molecule CD27 and its ligand CD70 participate in the immune pathogenesis of AA remains ill defined. METHODS:The frequencies of CD27/CD70 and perforin/granzyme B in different T cell subsets were detected in AA patients and healthy individuals by flow cytometry. RESULTS:We first time demonstrate a significantly elevated proportion of CD27⁺ and significantly decreased CD70⁺ T cells from AA. Changed frequency of CD27⁺ and CD70⁺ in different T cell subsets appeared to be associated with AA severity. In very severe aplastic anemia (VSAA) and severe aplastic anemia (SAA), increased CD8⁺CD27⁺ T cells present with a cytotoxic effector phenotype by elevating perforin proportion. CONCLUSIONS:Elevated proportion of CD27 in T cells may contribute to distinct immune pathogenesis for different severities of AA. The CD8⁺CD27⁺perforin⁺ T cells combined with CD8⁺CD70⁺ T cells may serve as an immune biomarker for AA severity estimation.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}