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Serum activities of dipeptidyl peptidase-4 and adenosine deaminase in polycystic ovary syndrome: association with obesity.

Gynecol. Endocrinol.2019 Aug;35(8):714-718. doi:10.1080/09513590.2019.1581165. Epub 2019 Mar 21
Seda Kahraman 1 , Alev Eroglu Altinova 2 , Serenay Elgun 3 , Mehmet Muhittin Yalcin 2 , Banu Aktas Yilmaz 2 , Cigdem Ozkan 2 , Mujde Akturk 2 , Fusun Balos Toruner 2
Seda Kahraman 1 , Alev Eroglu Altinova 2 , Serenay Elgun 3 , Mehmet Muhittin Yalcin 2 , Banu Aktas Yilmaz 2 , Cigdem Ozkan 2 , Mujde Akturk 2 , Fusun Balos Toruner 2
+ et al

[No authors listed]

Author information
  • 1 a Department of Internal Medicine , Faculty of Medicine, Gazi University , Ankara , Turkey.
  • 2 b Department of Endocrinology and Metabolism , Faculty of Medicine, Gazi University , Ankara , Turkey.
  • 3 c Department of Medical Biochemistry , Faculty of Medicine, Ankara University , Ankara , Turkey.

摘要


Dipeptidyl peptidase-4 (DPP-4) plays a role in metabolic and inflammatory diseases. Increased adenosine deaminase (ADA) has been suggested to induce insulin resistance and inflammation. We measured serum DPP-4 and ADA activities. Serum ADA activity was significantly higher in PCOS group (p = .006), whereas there was no difference in serum DPP-4 activity between the groups (p > .05). When the study subjects were divided into four groups in terms of obesity; an increasing trend in serum ADA activity between the groups was observed and ADA activity was significantly higher in overweight and obese patients with PCOS than nonobese controls (p = .016), there were no significant differences between the other groups (p > .05). A positive correlation was found between ADA and BMI in the whole group (p = .022). Multivariate regression analyses revealed that significant determinants were diastolic blood pressure, ADA, and the presence of PCOS for DPP-4 (R2 = 0.344, F = 9.079, p < .001); the presence of PCOS and DPP-4 for ADA (R2 = 0.123, F = 6.302, p = .003). We demonstrated increased serum ADA activity as well as its association with obesity in PCOS, while there was no change in serum DPP-4 activity in women with PCOS.

KEYWORDS: Adenosine deaminase, dipeptidyl peptidase-4, inflammation, obesity, polycystic ovary syndrome