Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca_v3.2 T-type voltage-gated calcium channel.

OBJECTIVES:Voltage-gated Ca²⁺ channels (VGCCs) are of central relevance in regulating Ca²⁺ influx into living cells. The low-voltage activated (LVA) Ca_v3 T-type Ca²⁺ channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Ca_v3.2 T-type Ca²⁺ channels seem to be of special importance as qPCR revealed a steady increase in Ca_v3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Ca_v3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Ca_v3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Ca_v3.2^+/+, Ca_v3.2^+/- and Ca_v3.2^-/- mice from both genders which are of value for researchers who want to evaluate how Ca_v3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies. DATA DESCRIPTION:Information presented here includes ABR data from age-matched female and male Ca_v3.2^+/+, Ca_v3.2^+/- and Ca_v3.2^-/- mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis.

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