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A study of the association between the sFlt-1/PIGF ratio and preeclampsia in Xinjiang Uygur Autonomous Region of China.

Artif Cells Nanomed Biotechnol. 2018;46(sup3):S281-S286. doi:10.1080/21691401.2018.1491480
Guifeng Ding 1 , Liu Liping 1 , Duan Moli 1 , Aibibula Wuliyeti 1 , Zhou Shaohe 2 , Wang Huijuan 2 , Peng Chen 3 , Chao Chen 2 , Bai Guiqin 4
Guifeng Ding 1 , Liu Liping 1 , Duan Moli 1 , Aibibula Wuliyeti 1 , Zhou Shaohe 2 , Wang Huijuan 2 , Peng Chen 3 , Chao Chen 2 , Bai Guiqin 4
+ et al

[No authors listed]

Author information
  • 1 b The Xinjiang Uygur Autonomous Region Maternal and Child Health Care Hospital , Urumqi , China.
  • 2 c The National Engineering Research Center for Miniaturized Detection Systems, Northwest University , Xi'an , China.
  • 3 d Institution of Basic Medical Science, Xi'an Medical University , Xi'an , China.
  • 4 a The First Affiliated Hospital of Medical College of Xi'an Jiaotong University , Xi'an , China.

摘要


AIM:It was previously reported that the ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) can predict the clinical onset of preeclampsia. This study seeks to validate the association between ratios of sFlt-1/PlGF with preeclampsia and to identify the contribution of ethnicity across diverse populations of the Xinjiang Uygur Autonomous Region. METHODS:Pregnant women were classified into those with preeclampsia (n = 136) and healthy controls (n = 350). Serum levels of sFlt-1 and PlGF were quantified using a Roche serum instrument in both patients and controls. RESULTS:Compared to healthy controls, women with preeclampsia had significantly higher levels of sFlt-1 (7303.81 pg/ml vs. 2508.69 pg/ml, p < .001) and ratios of sFlt-1/PlGF (241.68 vs. 14.29, p < .001), whereas levels of PIGF were decreased (241.68 vs. 14.29, p < .001). These three values varied greatly across nationalities, and non-Han Chinese subjects (including Uygur, Kazak, Hui) were more likely to experience severe preeclampsia than Han Chinese subjects. CONCLUSIONS:This is the first study to demonstrate that the ratio of sFlt-1/PlGF can both predict and serve as a diagnostic factor for preeclampsia in pregnant women from different populations within the Xinjiang region of China.

KEYWORDS: PlGF, multi-ethnic, preeclampsia, sFlt-1