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High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition.

Mol Med Rep. 2019 Apr;19(4):3190-3200. doi:10.3892/mmr.2019.9986. Epub 2019 Feb 25
Qiang Li 1 , Zhange Li 2 , Yuan Lin 2 , Hui Che 1 , Yingying Hu 3 , Xujuan Kang 2 , Ying Zhang 2 , Lihong Wang 1 , Yong Zhang 2
Qiang Li 1 , Zhange Li 2 , Yuan Lin 2 , Hui Che 1 , Yingying Hu 3 , Xujuan Kang 2 , Ying Zhang 2 , Lihong Wang 1 , Yong Zhang 2
+ et al

[No authors listed]

Author information
  • 1 Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
  • 2 Department of Pharmacology (The State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjang 150081, P.R. China.
  • 3 Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.

摘要


Hepatic fibrosis is characterized by the aberrant production and deposition of extracellular matrix (ECM) proteins. Growing evidence indicates that the epithelial‑mesenchymal transition serves a crucial role in the progression of liver fibrogenesis. Although a subset of microRNAs (miRNAs or miRs) has recently been identified as essential regulators of the EMT gene expression, studies of the EMT in hyperglycemic‑induced liver fibrosis are limited. In the current study, it was observed that high glucose‑treated AML12 cells occurred EMT process, and miR‑32 expression was markedly increased in the liver tissue of streptozotocin‑induced diabetic rats and in high glucose‑treated AML12 cells. Additionally, the contribution of the EMT to liver fibrosis by targeting metastasis‑associated gene 3 (MTA3) under hyperglycemic conditions was suppressed by AMO‑32. The results indicated that miR‑32 and MTA3 may be considered as novel drug targets in the prevention and treatment of liver fibrosis under hyperglycemic conditions. These finding improves the understanding of the progression of liver fibrogenesis.