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Non-redundant expression of the two katG genes in Vibrio parahaemolyticus V110.

J. Basic Microbiol.2019 May;59(5):535-541. doi:10.1002/jobm.201800325. Epub 2019 Feb 21
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摘要


Vibrio parahaemolyticus V110 is a marine origin pathogen infecting shrimp. Its resistance to oxidative stress is important for its survival in the complex marine ecosystems. vpa0768 (katG1) and vpa0453 (katG2) were previously found to contribute to the resistance against H2 O2 and isopropylbenzene. Our data showed that purified KatG2 and KatG1 possessed similar activity for hydrolyzing H2 O2 at 37 °C. The transcription of katG genes was induced by H2 O2 , cumene, and tert-butyl hydroperoxide (TBHP). The fold change of katG2 transcripts induced by isopropylbenzene was significantly higher than that of katG1. oxyR and rpoS are well-known regulatory genes which control the anti-oxidative and general stress response pathways, respectively. Deletion of rpoS resulted pathways, respectively. Deletion of rpoS resulted in abolishing the induction of katGs by the peroxides, and oxyR deletion only weakened the expression of the two genes. These results indicate that the two katGs encoding active enzymes are both inducible, but differ in their inducer preference. RpoS and oxyR are required for the full expression of katGs, but other unknown sensing regulators could be involved in the oxidative stress response besides OxyR.

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