Regulation of mitochondrial ROS production by HIC-5: a common feature of oncogene-induced senescence and tumor invasiveness?
FEBS J.2019 Feb;286(3):456-458. doi:10.1111/febs.14746. Epub 2019 Jan 25
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摘要
Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by matrix metalloproteases. Increased production of mitochondrial reactive oxygen species via NADPH oxidase 4 (NOX4) is implicated in this process. Hydrogen peroxide-inducible clone-5 (HIC-5) is postulated to sense both matrix detachment of transformed cells and intracellular and can inhibit ras signaling via inhibition of NOX4.
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原始数据
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文献解读
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