DSCAM-AS1 up-regulation in invasive ductal carcinoma of breast and assessment of its potential as a diagnostic biomarker.
[No authors listed]
摘要
BACKGROUND:The long non-coding RNA (lncRNA) DSCAM-AS1Â has been demonstrated to participate in the pathogenesis of breast cancer and tamoxifen resistance. OBJECTIVE:To evaluate expression profile of DSCAM-AS1Â in invasive ductal carcinoma of breast and its suitability as a biomarker for diagnosis of breast cancer. METHODS:We evaluated expression of DSCAM-AS1Â in 108 breast tissues including tumoral and adjacent non-cancerous tissues (ANCTs) by means of quantitative real time PCR. RESULTS:DSCAM-AS1Â was up-regulated in tumoral tissues compared with ANCTs (Fold change = 2.86, P =Â 0.011). Its expression was significantly higher in patients aged less than 55 compared with older patients (P =Â 0.02). However, its expression levels had not a good performance as a diagnostic biomarker for breast cancer. CONCLUSIONS:The significant up-regulation of DSCAM-AS1Â in tumoral tissues compared with ANCTs provides further evidences for participation of this lncRNA in the pathogenesis of breast cancer.
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基因功能
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原始数据
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文献解读
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