XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

Eur. J. Immunol.2019 Mar;49(3):504-507. doi:10.1002/eji.201847818. Epub 2019 Jan 03

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Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent.

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XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

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