The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment.
Front Immunol. 2018 Nov 28;9:2809. doi:10.3389/fimmu.2018.02809. eCollection 2018
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摘要
In cancer, immune exhaustion contributes to the immunosuppressive tumor microenvironment. Exhausted immune cells demonstrate poor effector function and sustained expression of certain immunomodulatory receptors, which can be therapeutically targeted. CD244 is a Signaling Lymphocyte Activation Molecule (SLAM) family immunoregulatory receptor found on many immune cell types-including NK cells, a subset of T cells, DCs, and MDSCs-that represents a potential therapeutic target. Here, we discuss the role of CD244 in tumor-mediated immune cell regulation.
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文献解读
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