例如:"lncRNA", "apoptosis", "WRKY"

Polymorphisms in the interleukin 4 receptor and interleukin 13 genes in immediate allergic reactions to beta-lactam antibiotics: A case-control study.

Asian Pac. J. Allergy Immunol.2019 Dec;37(4):212-219. doi:10.12932/AP-290318-0290
{{ author.authorName }}{{getOrganisationIndexOf(author)}} {{ author.authorName }}{{getOrganisationIndexOf(author)}}
{{ author.authorName }}{{getOrganisationIndexOf(author)}} {{ author.authorName }}{{getOrganisationIndexOf(author)}}
+ et al

[No authors listed]

Author information
  • {{index+1}} {{ organisation }}

摘要


BACKGROUND:Immediate hypersensitivity reactions to beta-lactams are IgE-mediated and constitute the most common adverse reactions to antibiotics mediated by a specific immunologic mechanism. OBJECTIVE:We investigated the association between four functional polymorphisms of IL13 (R130Q variant) and IL4RA (I50V, S478P and Q551R variants) genes and susceptibility to immediate allergic reactions to beta-lactams in the Algerian population. METHODS:We determined these gene variants in 199 patients and 99 healthy controls from Algeria. In a case-control study using the TaqMan method, we genotyped four single nucleotide polymorphisms (SNPs) including Arg130Gln in IL13, and Ile50Val, Ser478Pro as well as Gln551Arg in IL4RA. RESULTS:IL4RA I50V variant was more significantly connected with the risk of beta-lactam allergy (P = 0.0144) and the total serum IgE level in patients (P = 0.0136). A significant correlation was observed between IL13 R130Q and beta- lactam allergy (P = 0.0384). Also, a significant gene-gene interaction was detected between the predominant allele of the IL13 R130Q polymorphism and the three polymorphisms of IL4RA (P < 0.0001, P = 0.0163, and 0.0301, respectively). Haplotype analysis of IL4RA revealed that GTA haplotype had a significant correlation in patients with beta-lactam allergy (P = 0.0123). CONCLUSIONS:Our results indicate that IL4RA (I50V) and IL13 R130Q are associated with beta-lactam allergy. The combination of IL13 and IL4RA variants markedly increases an individual's susceptibility to beta-lactam allergy in the Algerian population.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}

基因功能


  • {{$index+1}}.{{ gene }}

图表


原始数据


 保存测序数据
Sample name
Organism Experiment title Sample type Library instrument Attributes
{{attr}}
{{ dataList.sampleTitle }}
{{ dataList.organism }} {{ dataList.expermentTitle }} {{ dataList.sampleType }} {{ dataList.libraryInstrument }} {{ showAttributeName(index,attr,dataList.attributes) }}

文献解读